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Stafford Hockey Club • View topic - pounds. Listen to your b
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Postby xuezhiqian123 » Wed Nov 21, 2018 2:34 am
"


WASHINGTON, May 18 (Xinhua) -- A large-scale clinical trial will begin in South Africa later this year to test the safety and efficacy of a promising investigational HIV vaccine regimen, a U.S. government health agency said Wednesday.


A smaller initial trial in South Africa has determined that the regimen consisting of two experimental vaccines is safe and produces a robust immune response, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) said in a statement.


""A safe and effective HIV vaccine could help bring about a durable end to the HIVAIDS pandemic and is particularly needed in southern Africa, where HIV is more pervasive than anywhere else in the world,"" said Anthony Fauci, director of NIAID, part of the U.S. National Institutes of Health and a co-funder of the trial.


The new study, called HVTN 702, will take place at 15 sites in South Africa beginning in November, pending regulatory approval.


Results of the study, to be led by Glenda Gray, president and chief executive officer of the South African Medical Research Council, are expected in late 2020.


About 5,400 healthy men and women aged 18 to 35 years who are at risk for HIV infection will be enrolled.


All study participants will receive a total of five injections over one year and they will be randomly assigned to receive either the investigational vaccine regimen or a placebo.


The HVTN 702 vaccine regimen consists of two experimental vaccines: a canarypox-based vaccine called ALVAC-HIV and a bivalent gp120 protein subunit vaccine with an adjuvant that enhances the body's immune response to the vaccine.


The current regimen is modified from the one investigated in the U.S. Military HIV Research Program-led RV144 clinical trial in Thailand that delivered landmark results in 2009.


The experimental vaccine regimen tested in the RV144 trial was found to be 31.2 percent effective at preventing HIV infection during the 3.5 years after vaccination.


In the new study, the design and schedule of the RV144 vaccine regimen have been adjusted to try to increase the magnitude and duration of vaccine-elicited immune responses in South African adults.


""HVTN 702 will tell us whether the initial success ... will bear fruit in the form of a safe and effective HIV vaccine designed for the people of southern Africa,"" said Gray, also research professor at the University of the Witwatersrand, and director of the Perinatal HIV Research Unit at South Africa's Chris Hani Baragwanath Hospital. Enditem

" Weight lifting programs for starters is an healthy way for men and women to start getting into shape. Occasionally people convey weightlifting to enormous and perfectly sculpted weight lifters. This will be a great beginner workout program as you can conveniently add this to any extra sport , cardio or outdoor hobby you already take pleasure in.

How Many Days a Week Should A Trainee Weigh Lift?

Generally, the maximum days that a learner should weight lift is three. If you over due the first week you will grow to be very soar and there is a increased chance you will quite after the first strenuous week. Once the beginner becomes more experienced , he or she can add in a few days with at least one rest day. Most novice weight lifting programs emphasize this three day a week plan. Another factor to consider besides how many days one weight lifts, is how much he or she is lifting. You should start off with a weight that you are happy with , so as not to pull your muscles. Depending on the goal you have set out for yourself it is a good thought to slowly over a couple of weeks to increase the weight and the repetitions. This will assist you to see your growth and remove injury as this is a slow progression to hitting your goal

Trendy Type of Beginner Weight Lifting Programs

The pyramid principle is a very popular program which has been in effect since Arnold Swarzeneger was in Diapers. This principle basically means that as your decrease the number of reps in the sets, you intensify the weight. For example , in the first set you may do 14 reps of squats. In the second set, you would complete 12 reps with a increased weight. The third set would be the same number of reps and weight used in the second rep while in the fourth set of squats you would finish 8 reps with an increased weight.

Why is the Pyramid Principle Ideal?

Many people who use the pyramid principle in their workout use it as a way to condition their muscles and to grow to be stronger by always increasing their weights. This plan is very valuable. Keep in mind as a beginner not to over do the weights , less is more in the beginning and avoiding injury is the key to victory. Basically to perform the weight lifting program for starters based on the pyramid principle effectively, there are certified instructions to pursue. Try going to the gymnasium with a buddy as they will not only encourage you but will make a great spotter and you should have a spotter specially at the beginning. Your strength will be diverse from squats to curls or even bench presses so do listen to your body and tweak the weight to suit that part of your body. Keep in mind that it will take a few various workouts before you truly recognize what weight and reps work efficiently on each muscle.

How to Find the Proper Weights to Start with as a Trainee

To find your perfect weight basically pick up a smaller weight and try to do one rep with exact form , if you can complete this then you have found your weight. Once you have established your correct weight then you can slowly increase it by five pounds for the first week and on the second week you should increase it again by this time it will be to intensify by ten pounds. Listen to your body and don't over do the wei.
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